Product Name

H-Glu-OtBu CAS 45120-30-7

Basic Information

CAS No:45120-30-7
Molecular Formula:C9H17NO4
Molecular Weight:203.236
Remarks:Factory direct sales

H-Glu-OtBu Properties

Item

Specifications

Appearance

White Powder

Purity/%

99.9%

Melting point/℃140
PSA89.62
density(Kg/m³)1400(rough estimate)
refractive index1.476
Flash point/℃151.5
storage temproom temperature

H-Glu-OtBu USES

H-Glu-OtBu is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical pharmaceutical synthesis processes.

As a linker for PROTAC (protein degradation targeting chimera), it plays an important role in drug development. PROTAC is a novel drug molecule that acts by inducing degradation of target proteins. H-Glu-OtBu, as a link-agent, can link the target protein to E3 ubiquitin ligase, thereby promoting the ubiquitization and subsequent degradation of the target protein. This mechanism enables PROTAC to achieve efficient and selective degradation of specific target proteins.

Secondly, H-Glu-OtBu can also be used as a connector for ADC (Antibody drug Conjugate). Adcs are a class of drugs that conjugate cellular agents to antibodies via a connector to achieve a precise strike on a specific antigen-expressing cell. H-Glu-OtBu acts as a linker to stably link cellular agents to antibodies while maintaining the stability and biological activity of the ADC. When the ADC binds to the antigen, the cell agent is released into the cell.

In addition, H-Glu-OtBu can also be used to prepare fatty diacid derivatives, which play a key role in the synthesis of insulin analogues. By introducing H-Glu-OtBu, the structure and properties of insulin analogues can be regulated to improve their pharmacodynamic and pharmacokinetic properties.

H-Glu-OtBu Packaging

Packing: 25Kg,100Kg,200Kg,1000Kg/Drum

H-Glu-OtBu storage

  1. Store barreled products in a cool, ventilated warehouse; keep away from

fire and heat sources. The warehousing temperature does not exceed 30 ℃, and the relative

humidity does not exceed 80%. Keep the container sealed; products should be stored separately

from oxidants, reducing agents, etc., and should not be mixed; be equipped with fire-fighting

equipment of appropriate variety and quantity; the storage area should be equipped with

equipment for emergency treatment of leakage and suitable containment materials;

  1. Store in a special storage tank; keep away from fire and heat sources; there is fire-fighting foam

for a fire emergency, and the tank area is equipped with equipment for the emergency treatment of

leakage.

  1. Shelf life: The shelf life of this product is 6 months.

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